Endometriosis and Ovarian Cancer

A recent US study followed nearly half a million women for 12 years. 79,000 women had been diagnosed with endometriosis at an average age of 36, and 372,000 age-matched controls without endometriosis. It has revealed a significant connection between endometriosis and a heightened risk of ovarian cancer.

The worse the endometriosis the higher the risk

The findings, led by researchers from the University of Utah, indicate that women with endometriosis are over four times more likely to develop ovarian cancer compared to those without the condition. Notably, women with severe subtypes of endometriosis, such as deep infiltrating endometriosis and ovarian endometriomas, face an almost 10-fold increased risk.

Cause is multifactorial

The exact mechanisms linking endometriosis to ovarian cancer remain unclear, but is thought to be multifactorial. Researchers suggest a potential genetic predisposition and overlapping hormonal, immunological, and inflammatory markers

Next Steps

Given these findings, women with endometriosis, particularly those with severe subtypes, may benefit from counselling regarding their ovarian cancer risk. Additionally, for women who have completed childbearing or have alternative fertility options, more definitive surgical interventions might be worth considering.

This research underscores the importance of targeted screening and prevention strategies for women with endometriosis to better manage and mitigate their elevated risk of ovarian cancer.

If you suspect you have endometriosis or pelvic pain and you would like to know how we can help, please see our endometriosis and pelvic pain specific page or complete our online questionnaire for one of our nurses to call you back. Otherwise please email us clinic@hhmp.com.au or call 9817 2080

Resources:

The study: Endometriosis Typology and Ovarian Cancer Risk 

JAMA Editorial: New Insights into Endometriosis Subtypes and Ovarian Cancer Risk